Stress and Vitiligo: Cause or Consequence?

Vitiligo is a skin condition characterized by loss of pigmentation in certain areas of the body due to the destruction of melanocytes. This condition can have a significant psychological impact. Individuals affected may experience anxiety and stress due to the altered appearance of their skin, which can affect their self-esteem. This stress is often exacerbated by social stigma and challenges in accepting the condition.

A study hypothesized that patients suffering from vitiligo are more prone to stress than those who are not affected. For this, 102 patients were analyzed with 54.8% being men and 45.2% women, considering that women are often more prone to stress than men. Patients are more concerned about vitiligo developing in the most visible areas of their skin, which is why the study tracked the development of vitiligo in different parts of the body, especially on visible areas. They found that individuals with vitiligo had more difficulty managing stress than the control group. Indeed, the study mentions an average PSS score (Perceived Stress Scale), which measures the stress level, was higher in patients with vitiligo (19.3%), compared to the control group (13.8%), suggesting that these patients experience a higher level of stress. Although in this study neither age, duration of vitiligo, nor disease status were associated with the perception of stress and the PSS only measures a person's perception of stress over the past few months, one could question the different factors that could explain the onset of this stress other than vitiligo.

Another study sought to evaluate the association between stress-related hormone levels and psychological stress in individuals with vitiligo. The 46 patients studied frequently experienced stress and anxiety, partly due to the stigma associated with the disease. The aim was therefore to determine the impact of stress hormones on this population. The results show that the levels of cortisol and dehydroepiandrosterone (DHEAS), a hormone associated with stress resistance, do not significantly differ between patients with vitiligo and healthy individuals. Indeed, the average DHEAS was 192.31 in patients versus 224.82 in unaffected individuals. Moreover, the probability value obtained (P = 0.158) is above the threshold of 0.05 required to conclude a significant difference. These results, therefore, do not confirm a clear difference between the two groups.

However, a more in-depth analysis showed that, despite the lack of significant statistical difference, healthy individuals generally had higher levels of DHEAS. This suggests that patients with vitiligo might have a diminished ability to manage stress. DHEAS indeed plays a crucial role in the modulation of cortisol effects, the stress hormone. A low level of DHEAS limits this natural protection, which could worsen the psychological state of patients. Additionally, DHEAS has antioxidant properties, helping to reduce oxidative stress. A deficiency in DHEAS could thus contribute to the worsening of depigmented lesions observed in vitiligo.

However, due to the small number of participants and the lack of significant results, further research is needed to establish a clear link between vitiligo and stress management impairment.